The talk of the effectiveness of hydroxychloroquine in treatment of COVID-19 is often advocated for by those physicians who use it in combination with Zinc (a common nutritional supplement). Many studies, including a recent report by Horbym and Landray (2020), however have indicated that hydroxychloroquine has not been shown to be effective in treatment of COVID-19. The question then is, on what grounds are those claiming hydroxychloroquine being effective in treatment of coronavirus infection emanating from?
Advocates of effectiveness of hydroxychloroquine claim that evidence is obtained from their practical clinical practices. They use hydroxychloroquine in combination with zinc and have witnessed a hands on life-saving experience, attributing treatment success to hydroxychloroquine. However, are these assertions true? Apparently yes - a combination of hydroxychloroquine and zinc is believed to be effective in treating COVID-19, but of the two entities, the main player in the treatment process is not hydroxychloroquine, but zinc. Hydroxychloroquine is known to play a facilitating role, as noted by Nyandat (2020), that “Much of what makes Hydroxychloroquine effective in combination with Zinc is believed to be its Zinc Ionophore capability. That is, the ability for Hydroxychloroquine to transport Zinc into cells and inhibit viral replication.” A study by Carlucci and others (2020), comparing hydroxychloroquine and azithromycin plus zinc versus hydroxychloroquine and azithromycin alone, may also help to explain the therapeutic effectiveness where zinc (Zn2+) is present. In any case, while evidence of plausible effect-inducing mechanism/mode of action for zinc in the prophylaxis or treatent of COVID-19 has been documented or demonstrated (Wessels, Rolles & Rink, 2020 and Kumar et al., 2020), there has been no evidence or documentation of a plausible effect-inducing mechanism of action in hydroxycloroquine or chloroquine.
However, in view of the potential risk of side effects associated with hydroxychloroquine, it’s zinc-ionophore capability role can be replaced by alternative zinc ionophores such as hinokitiol or pyrithione to enable use of zinc for prophylactic and therapeutic purposes against COVID-19, Nyandat (2020) and Wessels, Rolles & Rink (2020).
Take Home Message:
Attributing hydroxychloroquine to effectiveness of prophylaxis or treatment of COVID-19 in a combined hydroxychloroquine and zinc protocol is a misunderstanding and/or misinterpretation of science
While there is ample evidence of plausible effect-inducing mechanisms/modes of action for zinc in the prophylaxis or treatment of COVID-19, there appears to be no evidence or documentation of a plausible effect-inducing mechanisms of action in hydroxycloroquine or chloroquine, in the treatment of COVID-19.
The food as medicine (nutritional supplement) intervention approach has been shown to play an effective role in prophylaxis or treatment of COVID-19 and other respiratory viral infections, in contrast to the hydroxycloroquine, chloroquine or azithromycin prescription drugs.
Carlucci, P, Ahuja, T, Petrilli, C.M. Rajagopalan, H. Jones, S. and Rahimian, J (2020). Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients. COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv. Available at: https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1
Horbym P and Landray, M (2020). No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19. Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine, 5 June 2020. Available at: https://www.recoverytrial.net/files/hcq-recovery-statement-050620-final-002.pdf
Kumar, A., Kubota, Y., Chernov, M., & Kasuya, H. (2020). Potential role of zinc supplementation in prophylaxis and treatment of COVID-19. Medical hypotheses, 144, 109848. Advance online publication. https://doi.org/10.1016/j.mehy.2020.109848
Nyandat, J (2020). The Japanese Alternative to Hydroxychloroquine: Zinc + Hinokitiol. Press Release. MarketWatch. Available at: https://www.marketwatch.com/press-release/the-japanese-alternative-to-hydroxychloroquine-zinc-hinokitiol-2020-06-09
Wessels, I., Rolles, B., and Rink, L (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in Immunology. 11. 1712. 10.3389/fimmu.2020.01712. Available at: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01712/full
Popular posts from this blog
The concepts of nature cure as a natural health approach was well elucidated in the early 20th Century by one of the first pioneer authors Henry Lindlahr, in one of his book series of nature cure as follows: “ It is vastly more than a system of curing aches and pains; it is a complete revolution in the art and science of living. It is the practical realization and application of all that is good in natural science, philosophy and religion. “The philosophy of Nature Cure is based on sciences dealing with newly discovered or rediscovered natural laws and principles, and with their application to the phenomena of life and death, health, disease and cure”. Use of nature cure as an enabler for being the boss of your own health (taking charge of your own health) is based on the simplicity of the nature cure approach as compared to the orthodox medical approach in addressing health matters. Lindlahr (1922) argues that nature cure is considered an “exact science”, which reduces com
Effects of the coronavirus infection are variably uneven around the globe. Messaging on intervention measures is also featuring in two distinct dimensions, one (inclined towards the biomedical model)represented by countries such as the USA, the UK, Brazil, etc. is centred on long term plans for the search for therapeutic drugs and vaccines against COVID-19. The second dimension is aligned to alternative or integrative health intervention approaches, represented largely by counties in the Asian region including China, advocate for inclusion of natural health healing modalities (use of foods, nutritional supplements, herbs, etc.). The challenge is: are the so called health experts and/or policy makers still guided by science-based evidence on their advisory messaging and if so, where is the science and where is the evidence to help the world contain the scourge of COVID-19 pandemic? Here are a few highlights of emerging findings of some recent studies, in support or dismissing c